Introduction
The pharmaceutical industry has shown increasing interest in plant-derived polymers due to their diverse applications. These natural polymers serve as diluents, binders, disintegrants in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels, and bases in suppositories.
The Shift Towards Natural Excipients
Advancements in drug delivery technology have led to the inclusion of excipients in novel dosage forms. These excipients now play a direct or indirect role in drug release and absorption. The growing demand for plant-based alternatives has driven the replacement of synthetic additives with natural ones. Natural excipients offer benefits such as chemical inertness, non-toxicity, affordability, biodegradability, and wide availability.
Properties of Damar Gum and Mucilages
Damar gum and mucilages provide valuable polymers for pharmaceutical formulations. Their high water-swellability, non-toxicity, low cost, and abundance make them ideal excipients. As polysaccharides or complex carbohydrates, they consist of monosaccharides linked in various structures.
Role in Tablet Formulation
Damar gum and mucilages act as binders in tablet formulations due to their adhesive nature. They enhance cohesiveness, converting powder into granules for compression into tablets. Additionally, their disintegrating properties make them effective excipients.
Use in Sustained Release Formulations
Among different dosage forms, matrix tablets have gained popularity for sustained drug release. These systems control the drug’s dissolution and absorption rate. Direct compression of a blend of drug, retardant material, and additives simplifies the formulation process.
Polymeric Materials in Drug Release
Pharmaceutical scientists incorporate polymeric materials into matrix systems to modulate drug release effectively. Researchers continue to explore natural gums and mucilages for sustained-release formulations. Natural polymers and their semi-synthetic derivatives remain an active research area in drug delivery.
Compatibility and Effectiveness
FT-IR and DSC studies confirm that no chemical interaction occurs between the drug and polymer. Researchers have successfully prepared sustained-release matrix tablets of Metoprolol Succinate using Damar gum as the release-retarding material. Dicalcium phosphate and microcrystalline cellulose serve as diluents.
Modulating Drug Release with Damar Gum
Damar gum and dicalcium phosphate in the matrix help regulate drug release for an optimal pharmacokinetic profile. The strong binding properties and hydrophobicity of Damar gum ensure prolonged drug release.
Damar Gum Suppliers
Contact Information:
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